MOTS-C

MOTS-C is a mitochondria-encoded peptide derived from the 12S rRNA region of mitochondrial DNA. It plays a key role in metabolic regulation, cellular stress adaptation, and energy balance. Studies suggest that MOTS-C influences insulin sensitivity and AMPK activation, supporting mitochondrial function and resilience under metabolic stress. It has been investigated for its potential role in aging, endurance, and cellular protection.